CFT1946
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| Drug Name | CFT1946 |
| Trade Name | |
| Synonyms | CFT-1946|CFT 1946 |
| Drug Descriptions |
CFT1946 is a bifunctional degradation activation compound (BiDAC) degrader composed of a ligand that targets the BRAF kinase domain linked to a Cereblon ligand, which potentially induces degradation of mutant BRAF and inhibition of tumor growth (Cancer Res 2022;82(12_Suppl):Abstract nr 2158). |
| DrugClasses | BRAF Inhibitor 26 |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cetuximab + CFT1946 | CFT1946 Cetuximab | 0 | 1 |
| CFT1946 | CFT1946 | 2 | 1 |
| CFT1946 + Trametinib | CFT1946 Trametinib | 0 | 1 |
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