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Drug Name CISH-inactivated autologous TILs
Trade Name
Synonyms Autologous CISH-inactivated TILs|CISH inactivated TIL
Drug Descriptions

CISH-inactivated autologous TILs are patient-derived tumor infiltrating lymphocytes engineered to have disruption of cytokine-induced SH2 protein (CISH), which potentially results increased anti-tumor immune response (PMID: 36007524).

DrugClasses
CAS Registry Number NA
NCIT ID C151926

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldesleukin + CISH-inactivated autologous TILs + Cyclophosphamide + Fludarabine Aldesleukin CISH-inactivated autologous TILs Cyclophosphamide Fludarabine 0 2
CISH-inactivated autologous TILs CISH-inactivated autologous TILs 0 0
CISH-inactivated autologous TILs + unspecified PD-1 antibody CISH-inactivated autologous TILs unspecified PD-1 antibody 0 0


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