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Drug Name | HCW9218 |
Trade Name | |
Synonyms | HCW-9218|HCW 9218 |
Drug Descriptions |
HCW9218 is a fusion protein complex composed of TGFBR2 extracellular domains, a variant of IL15, and IL15RA sushi domains, which binds to and sequesters TGFB1, reducing downstream signaling and potentially increases antitumor immune response and tumor cell death (PMID: 34091051, PMID: 35051615). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C186737 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Docetaxel + HCW9218 | Docetaxel HCW9218 | 0 | 0 |
Gemcitabine + HCW9218 + Nab-paclitaxel | Gemcitabine HCW9218 Nab-paclitaxel | 0 | 0 |
HCW9218 | HCW9218 | 0 | 2 |