RMC-4998
Drug Detail
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| Drug Name | RMC-4998 |
| Trade Name | |
| Synonyms | RMC4998|RMC 4998 |
| Drug Descriptions |
RMC-4998 is a small molecule that selectively inhibits active KRAS G12C by forming a tri-complex with KRAS G12C and cyclophilin A, potentially resulting in decreased RAS signaling and tumor cell proliferation, and reduced tumor growth (PMID: 37590355). |
| DrugClasses | KRAS G12C inhibitor 36 |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| RMC-4550 + RMC-4998 + unspecified CTLA4 antibody | RMC-4550 RMC-4998 unspecified CTLA4 antibody | 0 | 0 |
| RMC-4550 + RMC-4998 + unspecified PD-1 antibody | RMC-4550 RMC-4998 unspecified PD-1 antibody | 0 | 0 |
| RMC-4998 | RMC-4998 | 0 | 0 |
| RMC-4998 + RMC-7977 | RMC-4998 RMC-7977 | 0 | 0 |
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