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Drug Name RMC-4998
Trade Name
Synonyms RMC4998|RMC 4998
Drug Descriptions

RMC-4998 is a small molecule that selectively inhibits active KRAS G12C by forming a tri-complex with KRAS G12C and cyclophilin A, potentially resulting in decreased RAS signaling and tumor cell proliferation, and reduced tumor growth (PMID: 37590355).

DrugClasses KRAS G12C inhibitor 34
CAS Registry Number NA
NCIT ID NA

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Therapy Name Drugs Efficacy Evidence Clinical Trials
RMC-4550 + RMC-4998 + unspecified CTLA4 antibody RMC-4550 RMC-4998 unspecified CTLA4 antibody 0 0
RMC-4550 + RMC-4998 + unspecified PD-1 antibody RMC-4550 RMC-4998 unspecified PD-1 antibody 0 0
RMC-4998 RMC-4998 0 0
RMC-4998 + RMC-7977 RMC-4998 RMC-7977 0 0


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