NKT3447
Drug Detail
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| Drug Name | NKT3447 |
| Trade Name | |
| Synonyms | NKT-3447|NKT 3447 |
| Drug Descriptions |
NKT3447 selectively inhibits CDK2 and disrupts the CDK2/CCNE1 and CDK2/CCNA2 complexes, which results in decreased Ccne1 and inhibition of Rb1 phosphorylation, potentially leading to cell cycle arrest and inhibition of tumor growth (Cancer Res (2024) 84 (6_Supplement): 5705). |
| DrugClasses | CDK2 Inhibitor 31 |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Carboplatin + NKT3447 | Carboplatin NKT3447 | 0 | 0 |
| NKT3447 | NKT3447 | 0 | 1 |
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