Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Drug Name | NKT3447 |
Trade Name | |
Synonyms | NKT-3447|NKT 3447 |
Drug Descriptions |
NKT3447 selectively inhibits CDK2 and disrupts the CDK2/CCNE1 and CDK2/CCNA2 complexes, which results in decreased Ccne1 and inhibition of Rb1 phosphorylation, potentially leading to cell cycle arrest and inhibition of tumor growth (Cancer Res (2024) 84 (6_Supplement): 5705). |
DrugClasses | CDK2 Inhibitor 31 |
CAS Registry Number | NA |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + NKT3447 | Carboplatin NKT3447 | 0 | 0 |
NKT3447 | NKT3447 | 0 | 1 |