AT-101
Drug Detail
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| Drug Name | AT-101 |
| Trade Name | |
| Synonyms | R-(-)-gossypol acetic acid|AT101 |
| Drug Descriptions |
AT-101 is a pan-BCL2 inhibitor that inhibits the anti-apoptotic proteins BCL2, BCL-XL, and MCL1, potentially resulting in increased tumor cell apoptosis and decreased cell proliferation (PMID: 26089640, PMID: 16611409, PMID: 31388792). |
| DrugClasses | BCL2 Family Inhibitor 6 |
| CAS Registry Number | 866541-93-7 |
| NCIT ID | C78348 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AT-101 | AT-101 | 0 | 1 |
| AT-101 + Bicalutamide | AT-101 Bicalutamide | 0 | 0 |
| AT-101 + Carboplatin + Paclitaxel | AT-101 Carboplatin Paclitaxel | 0 | 0 |
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