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Drug Name | CI-1040 |
Trade Name | |
Synonyms | PD184352|PD-184352 |
Drug Descriptions |
CI-1040 (PD184352) binds and inhibits Mek1 and Mek2, which may inhibit the activation of downstream signaling targets and reduce tumor cell proliferation (PMID: 14613031, PMID: 16009947). |
DrugClasses | MEK inhibitor (Pan) 26 MEK1 Inhibitor 26 MEK2 Inhibitor 24 |
CAS Registry Number | 212631-79-3 |
NCIT ID | C2670 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Afatinib + CI-1040 | Afatinib CI-1040 | 0 | 0 |
CI-1040 | CI-1040 | 28 | 0 |
CI-1040 + WZ4002 | CI-1040 WZ4002 | 0 | 0 |