GSK2126458
Drug Detail
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| Drug Name | GSK2126458 |
| Trade Name | |
| Synonyms | GSK458|Omipalisib |
| Drug Descriptions |
Omipalisib (GSK2126458) is a dual pan-PI3K and mTOR inhibitor, which blocks PI3K/AKT signaling to prevent cell proliferation (PMID: 24900173, PMID: 32382996). |
| DrugClasses | mTOR Inhibitor 51 PI3K Inhibitor (Pan) 42 |
| CAS Registry Number | 1086062-66-9 |
| NCIT ID | C88270 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Dabrafenib + GSK2126458 | Dabrafenib GSK2126458 | 6 | 0 |
| Dasatinib + GSK2126458 | Dasatinib GSK2126458 | 0 | 0 |
| GSK2126458 | GSK2126458 | 9 | 0 |
| GSK2126458 + Lapatinib | GSK2126458 Lapatinib | 0 | 0 |
| GSK2126458 + RXDX-105 | GSK2126458 RXDX-105 | 1 | 0 |
| GSK2126458 + Trametinib | GSK2126458 Trametinib | 7 | 0 |
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