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| Drug Name | Emibetuzumab |
| Trade Name | |
| Synonyms | LY2875358 |
| Drug Descriptions |
Emibetuzumab (LY2875358) is MET-targeted antibody, which inhibits binding of the MET ligand HGF and promotes internalization and downregulation of MET, resulting in decreased HGF-dependent and HGF-independent signaling and potentially leading to decreased growth of MET-expressing tumors (PMID: 27803065, PMID: 25231402, PMID: 31622732). |
| DrugClasses | MET Antibody 36 MET Inhibitor 59 |
| CAS Registry Number | 1365287-97-3 |
| NCIT ID | C95732 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Emibetuzumab | Emibetuzumab | 0 | 2 |
| Emibetuzumab + Erlotinib | Emibetuzumab Erlotinib | 0 | 2 |
| Emibetuzumab + Ramucirumab | Emibetuzumab Ramucirumab | 0 | 1 |
| Emibetuzumab + Trametinib | Emibetuzumab Trametinib | 0 | 1 |
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