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Drug Name | Motesanib Diphosphate |
Trade Name | |
Synonyms | AMG 706|AMG706|AMG-706 |
Drug Descriptions |
Motesanib Diphosphate (AMG 706) is a multi-kinase inhibitor, which inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and inducing tumor regression (PMID: 16951187, PMID: 21422803, PMID: 30816494). |
DrugClasses | KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 RET Inhibitor 53 VEGFR Inhibitor (Pan) 36 |
CAS Registry Number | 857876-30-3 |
NCIT ID | C48374 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + Motesanib Diphosphate | Carboplatin Motesanib Diphosphate | 0 | 0 |
Carboplatin + Motesanib Diphosphate + Paclitaxel | Carboplatin Motesanib Diphosphate Paclitaxel | 0 | 0 |
Motesanib Diphosphate | Motesanib Diphosphate | 5 | 0 |
Motesanib Diphosphate + Paclitaxel | Motesanib Diphosphate Paclitaxel | 0 | 0 |