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Drug Name | RO4929097 |
Trade Name | |
Synonyms | RG-4733 |
Drug Descriptions |
RO4929097 (RG-4733) is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 19773430, PMID: 31953695). |
DrugClasses | Gamma secretase inhibitor 13 |
CAS Registry Number | 847925-91-1 |
NCIT ID | C88333 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + Paclitaxel + RO4929097 | Carboplatin Paclitaxel RO4929097 | 0 | 0 |
Paclitaxel + RO4929097 | Paclitaxel RO4929097 | 0 | 0 |
Radiotherapy + RO4929097 + Temozolomide | RO4929097 Radiotherapy Temozolomide | 0 | 0 |
RO4929097 | RO4929097 | 0 | 1 |
RO4929097 + Vismodegib | RO4929097 Vismodegib | 0 | 1 |