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Drug Name RO4929097
Trade Name
Synonyms RG-4733
Drug Descriptions

RO4929097 (RG-4733) is a gamma secretase inhibitor, which blocks Notch cleavage and activation, and may inhibit angiogenesis and tumor growth (PMID: 19773430, PMID: 31953695).

DrugClasses Gamma secretase inhibitor 13
CAS Registry Number 847925-91-1
NCIT ID C88333

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + Paclitaxel + RO4929097 Carboplatin Paclitaxel RO4929097 0 0
Paclitaxel + RO4929097 Paclitaxel RO4929097 0 0
Radiotherapy + RO4929097 + Temozolomide RO4929097 Radiotherapy Temozolomide 0 0
RO4929097 RO4929097 0 1
RO4929097 + Vismodegib RO4929097 Vismodegib 0 1


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