Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Drug Name | VS-5584 |
Trade Name | |
Synonyms | SB-2343|SB2343|VS5584 |
Drug Descriptions |
VS-5584 (SB-2343) inhibits mTOR kinase and all class I PI3K isoforms, disrupting phosphorylation of substrates downstream of PI3K and mTOR, thereby preventing cell proliferation and inhibiting tumor growth (PMID: 23270925, PMID: 32286946). |
DrugClasses | mTOR Inhibitor 51 PI3K Inhibitor (Pan) 42 |
CAS Registry Number | 1246560-33-7 |
NCIT ID | C112497 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Defactinib + VS-5584 | Defactinib VS-5584 | 0 | 1 |
VS-5584 | VS-5584 | 5 | 1 |