VS-5584
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| Drug Name | VS-5584 |
| Trade Name | |
| Synonyms | SB-2343|SB2343|VS5584 |
| Drug Descriptions |
VS-5584 (SB-2343) inhibits mTOR kinase and all class I PI3K isoforms, disrupting phosphorylation of substrates downstream of PI3K and mTOR, thereby preventing cell proliferation and inhibiting tumor growth (PMID: 23270925, PMID: 32286946). |
| DrugClasses | mTOR Inhibitor 51 PI3K Inhibitor (Pan) 42 |
| CAS Registry Number | 1246560-33-7 |
| NCIT ID | C112497 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Defactinib + VS-5584 | Defactinib VS-5584 | 0 | 1 |
| VS-5584 | VS-5584 | 5 | 1 |
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