Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Serabelisib
Trade Name
Synonyms INK1117|TAK-117|MLN-1117|MLN1117
Drug Descriptions

Serabelisib (MLN1117) selectively inhibits PI3K alpha kinase, including mutations of PIK3CA, and therefore, targets the PI3K/Akt/mTOR pathway with potentially less toxicity than pan-PI3K inhibitors (PMID: 28490463, PMID: 30168905).

DrugClasses PIK3CA inhibitor 24
CAS Registry Number 1268454-23-4
NCIT ID C98844

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Mivavotinib + Serabelisib Mivavotinib Serabelisib 0 0
Nab-paclitaxel + Serabelisib Nab-paclitaxel Serabelisib 0 1
Paclitaxel + Sapanisertib + Serabelisib Paclitaxel Sapanisertib Serabelisib 0 1
Sapanisertib + Serabelisib Sapanisertib Serabelisib 0 4
Serabelisib Serabelisib 4 3


Additional content available in CKB BOOST