Riluzole
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| Drug Name | Riluzole |
| Trade Name | |
| Synonyms | Rilutek |
| Drug Descriptions |
Rilutek (riluzole) inhibits metabotropic glutamate receptors, which results in decreased signaling through the MAPK pathway and the PI3K/AKT pathway (PMID: 19458050), and also inhibits voltage-gated ion channels and may directly inhibit protein kinase C (PMID: 10964608, PMID: 32304618). |
| DrugClasses | PKC Inhibitor (Pan) 11 |
| CAS Registry Number | 1744-22-5 |
| NCIT ID | C47704 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + Riluzole | Bevacizumab Fluorouracil Leucovorin Oxaliplatin Riluzole | 0 | 1 |
| Riluzole | Riluzole | 0 | 0 |
| Riluzole + Sorafenib | Riluzole Sorafenib | 0 | 1 |
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