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Drug Name | REGN1400 |
Trade Name | |
Synonyms | REGN-1400|REGN 1400 |
Drug Descriptions |
REGN1400 is a monoclonal antibody, which binds to epidermal growth factor receptor B3 (Her3), preventing neuregulin 1 ligand binding, thereby inhibiting PI3K/Akt signaling and hence cellular proliferation (PMID: 24634416). |
DrugClasses | HER3 (ERBB3) Antibody 23 |
CAS Registry Number | NA |
NCIT ID | C103859 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cetuximab + REGN1400 | Cetuximab REGN1400 | 0 | 1 |
Erlotinib + REGN1400 | Erlotinib REGN1400 | 0 | 1 |
REGN1400 | REGN1400 | 0 | 1 |