Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Drug Name Apatorsen
Trade Name
Synonyms OGX-427|ISIS 306053|OGX427|OGX 427|ISIS-306053|ISIS 306053
Drug Descriptions

Apatorsen (OGX-427) is an antisense oligonucleotide that targets HSBP1 (HSP27), which reduces Hsbp1 expression, potentially resulting in increased tumor cell apoptosis and improved sensitivity to other anti-tumor therapies (PMID: 31420467).

DrugClasses Antisense Therapy 14
CAS Registry Number 1002331-21-6
NCIT ID C71740

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Apatorsen Apatorsen 0 3
Apatorsen + Carboplatin + Pemetrexed Disodium Apatorsen Carboplatin Pemetrexed Disodium 0 0
Apatorsen + Gemcitabine Apatorsen Gemcitabine 0 0


Additional content available in CKB BOOST