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Drug Name | CB-5083 |
Trade Name | |
Synonyms | CB5083|CB 5083 |
Drug Descriptions |
CB-5083 binds to and inhibits valosin-containing protein (VCP, p97) to activate the unfolded protein response, resulting in ER stress, apoptosis, and decreased tumor cell proliferation (PMID: 28878026, PMID: 29314493, PMID: 30606672, PMID: 30591537, PMID: 32655822). |
DrugClasses | |
CAS Registry Number | 1542705-92-9 |
NCIT ID | C118287 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
CB-5083 | CB-5083 | 0 | 2 |
CB-5083 + Dexamethasone | CB-5083 Dexamethasone | 0 | 1 |