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Drug Detail
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| Drug Name | ALRN-6924 |
| Trade Name | |
| Synonyms | CS-0044703 |
| Drug Descriptions |
ALRN-6924 (CS-0044703) binds to MDM2 and MDM4 (MDMX) and prevents their interaction with p53, resulting in restoration of p53 activity and potentially leading to increased tumor cell death (PMID: 29643228, PMID: 30253242). |
| DrugClasses | MDM2 Inhibitor 23 MDM4 inhibitor 8 |
| CAS Registry Number | NA |
| NCIT ID | C118669 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| ALRN-6924 | ALRN-6924 | 9 | 3 |
| ALRN-6924 + Carboplatin + Pemetrexed Disodium | ALRN-6924 Carboplatin Pemetrexed Disodium | 0 | 1 |
| ALRN-6924 + Cyclophosphamide + Docetaxel + Doxorubicin | ALRN-6924 Cyclophosphamide Docetaxel Doxorubicin | 0 | 1 |
| ALRN-6924 + Cytarabine | ALRN-6924 Cytarabine | 0 | 2 |
| ALRN-6924 + Paclitaxel | ALRN-6924 Paclitaxel | 0 | 1 |
| ALRN-6924 + Topotecan | ALRN-6924 Topotecan | 0 | 1 |
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