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Drug Name | Ipafricept |
Trade Name | |
Synonyms | Fzd8-Fc|OMP-54F28 |
Drug Descriptions |
Ipafricept (OMP-54F28) is a fusion protein comprised of the ligand binding domain of the Frizzled family receptor 8 and the human immunoglobulin Fc domain, which binds Wnt and prevents downstream signaling, thereby inhibiting tumor growth (PMID: 25172549, PMID: 32694153, PMID: 31174889). |
DrugClasses | WNT Inhibitor 16 |
CAS Registry Number | 1391727-24-4 |
NCIT ID | C102565 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + Ipafricept + Paclitaxel | Carboplatin Ipafricept Paclitaxel | 0 | 0 |
Gemcitabine + Ipafricept + Nab-paclitaxel | Gemcitabine Ipafricept Nab-paclitaxel | 0 | 0 |
Ipafricept | Ipafricept | 0 | 0 |
Ipafricept + Sorafenib | Ipafricept Sorafenib | 0 | 1 |