Ipafricept
Drug Detail
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| Drug Name | Ipafricept |
| Trade Name | |
| Synonyms | Fzd8-Fc|OMP-54F28 |
| Drug Descriptions |
Ipafricept (OMP-54F28) is a fusion protein comprised of the ligand binding domain of the Frizzled family receptor 8 and the human immunoglobulin Fc domain, which binds Wnt and prevents downstream signaling, thereby inhibiting tumor growth (PMID: 25172549, PMID: 32694153, PMID: 31174889). |
| DrugClasses | WNT Inhibitor 17 |
| CAS Registry Number | 1391727-24-4 |
| NCIT ID | C102565 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Carboplatin + Ipafricept + Paclitaxel | Carboplatin Ipafricept Paclitaxel | 0 | 0 |
| Gemcitabine + Ipafricept + Nab-paclitaxel | Gemcitabine Ipafricept Nab-paclitaxel | 0 | 0 |
| Ipafricept | Ipafricept | 0 | 0 |
| Ipafricept + Sorafenib | Ipafricept Sorafenib | 0 | 1 |
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