PV1019
Drug Detail
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| Drug Name | PV1019 |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
PV1019, a derivative of NSC109555, is an ATP-competitive inhibitor of CHK2, which leads to reduced CHK2 kinase activity and decreased tumor cell growth, and enhances the anti-tumor effects of chemotherapeutic agents (PMID: 19741151). |
| DrugClasses | CHK2 Inhibitor 7 |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Camptothecin + PV1019 | Camptothecin PV1019 | 0 | 0 |
| PV1019 | PV1019 | 0 | 0 |
| PV1019 + Radiotherapy | PV1019 Radiotherapy | 0 | 0 |
| PV1019 + Topotecan | PV1019 Topotecan | 0 | 0 |
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