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Drug Name | PV1019 |
Trade Name | |
Synonyms | |
Drug Descriptions |
PV1019, a derivative of NSC109555, is an ATP-competitive inhibitor of CHK2, which leads to reduced CHK2 kinase activity and decreased tumor cell growth, and enhances the anti-tumor effects of chemotherapeutic agents (PMID: 19741151). |
DrugClasses | CHK2 Inhibitor 7 |
CAS Registry Number | NA |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Camptothecin + PV1019 | Camptothecin PV1019 | 0 | 0 |
PV1019 | PV1019 | 0 | 0 |
PV1019 + Radiotherapy | PV1019 Radiotherapy | 0 | 0 |
PV1019 + Topotecan | PV1019 Topotecan | 0 | 0 |