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Drug Name | PLX9486 |
Trade Name | |
Synonyms | PLX-9486|PLX 9486|Bezuclastinib|CGT-9486|CGT9486|CGT 9486 |
Drug Descriptions |
PLX9486 is a Kit inhibitor with selective activity against primary (exon 9 and 11) and secondary (exon 17 and 18) Kit mutations, which may lead to growth inhibition in tumor cells expressing mutant c-Kit (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 11509-11509, PMID: 30523507). |
DrugClasses | KIT Inhibitor 57 |
CAS Registry Number | NA |
NCIT ID | C121647 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Pexidartinib + PLX9486 | PLX9486 Pexidartinib | 2 | 1 |
PLX9486 | PLX9486 | 9 | 4 |
PLX9486 + Sunitinib | PLX9486 Sunitinib | 0 | 3 |