PLX9486
Drug Detail
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| Drug Name | PLX9486 |
| Trade Name | |
| Synonyms | PLX-9486|PLX 9486|Bezuclastinib|CGT-9486|CGT9486|CGT 9486 |
| Drug Descriptions |
PLX9486 is a Kit inhibitor with selective activity against primary (exon 9 and 11) and secondary (exon 17 and 18) Kit mutations, which may lead to growth inhibition in tumor cells expressing mutant c-Kit (Journal of Clinical Oncology 36, no. 15_suppl (May 20 2018) 11509-11509, PMID: 30523507). |
| DrugClasses | KIT Inhibitor 57 |
| CAS Registry Number | NA |
| NCIT ID | C121647 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Midazolam + PLX9486 + Sunitinib | Midazolam PLX9486 Sunitinib | 0 | 1 |
| Pexidartinib + PLX9486 | PLX9486 Pexidartinib | 2 | 1 |
| PLX9486 | PLX9486 | 9 | 5 |
| PLX9486 + Sunitinib | PLX9486 Sunitinib | 0 | 4 |
CKB BOOST