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Drug Name | Navoximod |
Trade Name | |
Synonyms | NLG919|RG6078|GDC-0919|RO7077339-001 |
Drug Descriptions |
Navoximod (GDC-0919) inhibits indoleamine 2,3-dioxygenase 1 (IDO1), which decreases production of kynurenine from tryptophan, potentially resulting in reduced T-cell suppression and increased antitumor immune response (PMID: 31124055, PMID: 29247038). |
DrugClasses | IDO1 Inhibitor 12 |
CAS Registry Number | 1402837-78-8 |
NCIT ID | C113793 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + Navoximod | Atezolizumab Navoximod | 0 | 0 |
Navoximod | Navoximod | 0 | 2 |
Navoximod + NLG802 | NLG802 Navoximod | 0 | 1 |