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| Drug Name | Abivertinib |
| Trade Name | |
| Synonyms | Avitinib|AC0010|AC0010MA |
| Drug Descriptions |
Abivertinib (AC0010) is a BTK inhibitor and a third-generation EGFR inhibitor that blocks the activity of mutant forms of EGFR while sparing wild-type EGFR, which potentially results in increased apoptosis and cell cycle arrest, and decreased viability and colony formation, and inhibits tumor growth (PMID: 27573423, PMID: 31310800). |
| DrugClasses | BTK inhibitor 37 EGFR Inhibitor 3rd gen 26 |
| CAS Registry Number | 1557267-42-1 |
| NCIT ID | C147125 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Abiraterone + Abivertinib | Abiraterone Abivertinib | 0 | 1 |
| Abivertinib | Abivertinib | 1 | 1 |
| Abivertinib + Omacetaxine mepesuccinate | Abivertinib Omacetaxine mepesuccinate | 1 | 0 |
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