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Drug Name | PTC299 |
Trade Name | |
Synonyms | CS-0087039 |
Drug Descriptions |
PTC299 inhibits dihydroorotate dehydrogenase (DHODH), thereby preventing pyrimidine nucleotide synthesis, potentially resulting in decreased MYC expression and VEGFA production, and reduced tumor cell migration and proliferation (PMID: 30352802, PMID: 33496740). |
DrugClasses | |
CAS Registry Number | 1219951-09-3 |
NCIT ID | C91100 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
PTC299 | PTC299 | 0 | 1 |