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Drug Name | IDH305 |
Trade Name | |
Synonyms | IDH 305|IDH-305 |
Drug Descriptions |
IDH305 specifically targets IDH1 with mutations at amino acid R132, which results in decreased 2HG production and potentially leads to increased differentiation and decreased proliferation of IDH R132-mutant cancer cells (PMID: 29057061). |
DrugClasses | IDH1 Inhibitor 8 |
CAS Registry Number | NA |
NCIT ID | C121457 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
IDH305 | IDH305 | 3 | 2 |