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Drug Name | SP600125 |
Trade Name | |
Synonyms | |
Drug Descriptions |
SP600125 is an ATP-competitive inhibitor of JNK, with activity against JNK1, JNK2, and JNK3 and also TTK (Mps1), which may lead to cell-cycle inhibition and decreased growth of tumor cells (PMID: 19478553, PMID: 11717429, PMID: 16113653, PMID: 32835935). |
DrugClasses | JNK Inhibitor 5 MPS1 Inhibitor 27 |
CAS Registry Number | 129-56-6 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cetuximab + SP600125 | Cetuximab SP600125 | 0 | 0 |
Paclitaxel + SP600125 | Paclitaxel SP600125 | 0 | 0 |
SP600125 | SP600125 | 1 | 0 |