Narazaciclib
Drug Detail
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| Drug Name | Narazaciclib |
| Trade Name | |
| Synonyms | 7X|ON-123300|ON 123300|ON123300 |
| Drug Descriptions |
Narazaciclib (ON123300) inhibits CDK4 and ARK5 (NUAK1), resulting in decreased downstream signaling and increased tumor cell death (PMID: 24417566, PMID: 26873845). |
| DrugClasses | CDK4 Inhibitor 18 NUAK1 Inhibitor 3 |
| CAS Registry Number | 1357470-29-1 |
| NCIT ID | C179641 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Azacitidine + Narazaciclib | Azacitidine Narazaciclib | 1 | 0 |
| Cytarabine + Narazaciclib | Cytarabine Narazaciclib | 0 | 0 |
| Dexamethasone + Narazaciclib | Dexamethasone Narazaciclib | 0 | 1 |
| Letrozole + Narazaciclib | Letrozole Narazaciclib | 0 | 1 |
| Narazaciclib | Narazaciclib | 9 | 1 |
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