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Drug Name | Imetelstat |
Trade Name | Rytelo |
Synonyms | GRN163L|JNJ-63935937|GRN 163L |
Drug Descriptions |
Rytelo (imetelstat) inhibits telomerase activity, resulting in telomere shortening and potentially leading to increased tumor cell death (PMID: 20048334, PMID: 32571117). Rytelo (imetelstat) is FDA-approved for use in patients with myelodysplastic syndromes with transfusion-dependent anemia (FDA.gov). |
DrugClasses | |
CAS Registry Number | 868169-64-6 |
NCIT ID | C49084 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cytarabine + Fludarabine + Imetelstat | Cytarabine Fludarabine Imetelstat | 0 | 1 |
Imetelstat | Imetelstat | 0 | 3 |
Imetelstat + Radiotherapy | Imetelstat Radiotherapy | 0 | 0 |