Vantictumab
Drug Detail
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| Drug Name | Vantictumab |
| Trade Name | |
| Synonyms | anti-Fzd7|OMP-18R5 |
| Drug Descriptions |
Vantictumab (OMP-18R5) is a monoclonal antibody that targets Frizzled receptors 1, 2, 5, 7, and 8, resulting in decreased Wnt signaling and potentially leading to decreased tumor growth (PMID: 22753465, PMID: 31338636). |
| DrugClasses | WNT Inhibitor 17 |
| CAS Registry Number | 1345009-45-1 |
| NCIT ID | C96799 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Docetaxel + Vantictumab | Docetaxel Vantictumab | 0 | 1 |
| Gemcitabine + Nab-paclitaxel + Vantictumab | Gemcitabine Nab-paclitaxel Vantictumab | 0 | 1 |
| Gemcitabine + Vantictumab | Gemcitabine Vantictumab | 0 | 0 |
| Paclitaxel + Vantictumab | Paclitaxel Vantictumab | 0 | 1 |
| Vantictumab | Vantictumab | 1 | 0 |
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