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Drug Name | EAI045 |
Trade Name | |
Synonyms | EAI-045|EAI 045 |
Drug Descriptions |
EAI045 is a 4th generation, allosteric, non-ATP competitive inhibitor of epidermal growth factor receptor (EGFR) with selective activity against EGFR L858R/T790M and C797S, which when combined with anti-EGFR antibodies may lead to growth inhibition in tumors harboring EGFR T790M or C797S (PMID: 27251290, PMID: 27840244, PMID: 32666476). |
DrugClasses | EGFR Inhibitor 4th gen 16 |
CAS Registry Number | 1942114-09-1 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cetuximab + EAI045 | Cetuximab EAI045 | 0 | 0 |
EAI045 | EAI045 | 0 | 0 |
EAI045 + Osimertinib | EAI045 Osimertinib | 0 | 0 |