Pexmetinib
Drug Detail
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| Drug Name | Pexmetinib |
| Trade Name | |
| Synonyms | ARRY-614 |
| Drug Descriptions |
Pexmetinib (ARRY-614) inhibits Tie2, p38, and the BCR-ABL1 fusion, potentially leading to decreased cell proliferation and inhibition of tumor growth (PMID: 27287719, PMID: 25480830, PMID: 38750137). |
| DrugClasses | BCR-ABL Inhibitor 32 |
| CAS Registry Number | 945614-12-0 |
| NCIT ID | C85481 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Ipilimumab + Nivolumab + Pexmetinib | Ipilimumab Nivolumab Pexmetinib | 0 | 1 |
| Ipilimumab + Pexmetinib | Ipilimumab Pexmetinib | 0 | 0 |
| Nivolumab + Pexmetinib | Nivolumab Pexmetinib | 0 | 1 |
| Pexmetinib | Pexmetinib | 0 | 0 |
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