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Drug Name | HPVST cells |
Trade Name | |
Synonyms | Autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T Lymphocytes |
Drug Descriptions |
HPVST cells are autologous T cells that are stimulated with HPV-16/18-loaded dendritic cells and are also engineered to express a dominant-negative TGF-beta receptor II that inhibits TGF-beta signaling, which potentially results in increased T cell response against HPV-16/18-positive tumor cells (NCI Drug Dictionary). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C121537 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cyclophosphamide + Fludarabine + HPVST cells + Nivolumab | Cyclophosphamide Fludarabine HPVST cells Nivolumab | 0 | 1 |
HPVST cells | HPVST cells | 0 | 1 |