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Drug Name | I-BET151 |
Trade Name | |
Synonyms | GSK1210151A |
Drug Descriptions |
I-BET151 is a small molecule that blocks Brd3/4 binding to chromatin, resulting in transcription inhibition and potentially leading to tumor cell death (PMID: 21964340, PMID: 30906568, PMID: 32603665). |
DrugClasses | BRD3 Inhibitor 2 BRD4 Inhibitor 10 |
CAS Registry Number | 1300031-49-5 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Givinostat + I-BET151 | Givinostat I-BET151 | 0 | 0 |
I-BET151 | I-BET151 | 1 | 0 |
I-BET151 + Panobinostat | I-BET151 Panobinostat | 0 | 0 |
I-BET151 + Prednisolone | I-BET151 Prednisolone | 0 | 0 |
I-BET151 + SGC0946 | I-BET151 SGC0946 | 1 | 0 |
I-BET151 + Trametinib | I-BET151 Trametinib | 1 | 0 |