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Drug Name | SRF231 |
Trade Name | |
Synonyms | SRF 231|SRF-231 |
Drug Descriptions |
SRF231 is monoclonal antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (Blood 2016 128:1843, PMID: 28286286) and may also stimulate cytotoxic T-cells (PMID: 29873856, PMID: 32345627). |
DrugClasses | CD47 Antibody 31 Immune Checkpoint Inhibitor 149 |
CAS Registry Number | NA |
NCIT ID | C155976 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
SRF231 | SRF231 | 0 | 1 |