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Drug Name | NI-1801 |
Trade Name | |
Synonyms | NI 1801|NI1801 |
Drug Descriptions |
NI-1801 is a bispecific antibody to CD47 and mesothelin, designed to target tumor cells expressing mesothelin and block CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (PMID: 28286286) may also stimulate cytotoxic T-cells (PMID: 29873856). |
DrugClasses | CD47 Antibody 31 Immune Checkpoint Inhibitor 149 MSLN Antibody 12 |
CAS Registry Number | NA |
NCIT ID | C188247 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
NI-1801 | NI-1801 | 0 | 1 |