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| Drug Name | L-DOS47 |
| Trade Name | |
| Synonyms | L DOS47|LDOS47 |
| Drug Descriptions |
L-DOS47 comprises urease linked to a monoclonal antibody that targets CEACAM6, which targets urease to tumors, leading to local conversion of urea to ammonia and increased pH, potentially resulting in cytoxicity in tumor cells (J Thorac Oncol, Vol 12 , Issue 1, S1071-S1072, PMID: 25938892). |
| DrugClasses | CEACAM6 Antibody 3 |
| CAS Registry Number | NA |
| NCIT ID | C120068 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Carboplatin + L-DOS47 + Pemetrexed Disodium | Carboplatin L-DOS47 Pemetrexed Disodium | 0 | 1 |
| Doxorubicin + L-DOS47 | Doxorubicin L-DOS47 | 0 | 1 |
| L-DOS47 | L-DOS47 | 0 | 0 |
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