LY3499446
Drug Detail
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| Drug Name | LY3499446 |
| Trade Name | |
| Synonyms | LY-3499446|LY 3499446 |
| Drug Descriptions |
LY3499446 is an oral inhibitor of KRAS G12C that prevents constitutive downstream signaling to inhibit tumor cell proliferation and growth (PMID: 32014824). |
| DrugClasses | KRAS G12C inhibitor 36 |
| CAS Registry Number | NA |
| NCIT ID | C166410 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Abemaciclib + LY3499446 | Abemaciclib LY3499446 | 0 | 1 |
| Cetuximab + LY3499446 | Cetuximab LY3499446 | 0 | 1 |
| Erlotinib + LY3499446 | Erlotinib LY3499446 | 0 | 1 |
| LSN3321213 + LY3499446 | LSN3321213 LY3499446 | 0 | 0 |
| LY3499446 | LY3499446 | 0 | 1 |
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