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Drug Name | ROR1 CAR-T cells |
Trade Name | |
Synonyms | autologous ROR1-CAR-T cells |
Drug Descriptions |
ROR1 CAR-T cells are autologous T-lymphocytes engineered to express anti-ROR1 single-chain variable fragment linked to CD28 transmembrane domain, and either 4-1BB/CD3zeta or CD28/CD3zeta signaling domains, which potentially induces immune response against ROR1-expressing tumor cells, leading to apoptosis and tumor cell lysis (PMID: 31415244). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C117237 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cyclophosphamide + Fludarabine + ROR1 CAR-T cells | Cyclophosphamide Fludarabine ROR1 CAR-T cells | 0 | 1 |
ROR1 CAR-T cells | ROR1 CAR-T cells | 0 | 0 |