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Drug Name | MA242 |
Trade Name | |
Synonyms | MA 242|MA-242 |
Drug Descriptions |
MA242 binds to and inhibits MDM2 and NFAT1, leading to ubiquitination and degradation of MDM2, which may lead to apoptosis and inhibition of tumor cell growth and metastasis independent of Tp53 function (PMID: 30217928, PMID: 31181320). |
DrugClasses | MDM2 Inhibitor 23 |
CAS Registry Number | 1049704-18-8 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Gemcitabine + MA242 | Gemcitabine MA242 | 0 | 0 |
MA242 | MA242 | 0 | 0 |