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Drug Name | JNJ-64619178 |
Trade Name | |
Synonyms | JNJ64619178|JNJ 64619178 |
Drug Descriptions |
JNJ-64619178 is a PRMT5 inhibitor that binds to and inhibits the S-adenosylmethionine (SAM) and substrate-binding regions of the PRMT5/MEP50 complex, potentially reducing dimethylation of target proteins such as SMD1/3 and resulting in tumor growth inhibition (Cancer Res 2018;78(13 Suppl):Abstract nr 4859, PMID: 31312965). |
DrugClasses | PRMT5 Inhibitor 17 |
CAS Registry Number | 2086772-26-9 |
NCIT ID | C163980 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
JNJ-64619178 | JNJ-64619178 | 0 | 1 |