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Drug Name | Oncolytic HSV-1 rRp450 |
Trade Name | |
Synonyms | rRp450 |
Drug Descriptions |
Oncolytic HSV-1 rRp450 is an engineered oncolytic type-I herpes simplex virus 1 (HSV-1) that encodes CYP2B1, which activates cancer prodrugs including cyclophosphamide and enhances sensitivity to chemotherapy agents, potentially resulting in increased tumor cell lysis and reduced metastases (PMID: 12209705). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C90563 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cyclophosphamide + Oncolytic HSV-1 rRp450 | Cyclophosphamide Oncolytic HSV-1 rRp450 | 0 | 0 |
Oncolytic HSV-1 rRp450 | Oncolytic HSV-1 rRp450 | 0 | 1 |