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Gene Symbol | CTNNB1 | ||||||||||
Synonyms | armadillo | CTNNB | EVR7 | MRD19 | NEDSDV | ||||||||||
Gene Description | CTNNB1, catenin beta 1, is a member of the Wnt signaling pathway, component of cadherin-based adherens junctions, and is also a tumor antigen recognized by T-cells in melanoma (PMID: 29403496). CTNNB1 imbalance is implicated in cancer progression and metastasis (PMID: 22617422) and exon 3 mutations are common in endometrioid endometrial carcinoma and melanoma (PMID: 29435196). | ||||||||||
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