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Profile Name | CTNNB1 G34R |
Gene Variant Detail | |
Relevant Treatment Approaches | CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
CTNNB1 G34R | hepatocellular carcinoma | predicted - sensitive | Everolimus + Sorafenib | Case Reports/Case Series | Actionable | In a clinical case study, Afinitor (everolimus) and Nexavar (sorafenib) combination therapy resulted in a 50% tumor response after 3 months of treatment in a patient with metastatic hepatocellular carcinoma harboring CTNNB1 G34R whose disease progressed on prior Nexavar (sorafenib) monotherapy, and the response was ongoing at 8 months (PMID: 20347502). | 20347502 |