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Gene Symbol FGFR1
Synonyms bFGF-R-1 | BFGFR | CD331 | CEK | ECCL | FGFBR | FGFR-1 | FLG | FLT-2 | FLT2 | HBGFR | HH2 | HRTFDS | KAL2 | N-SAM | OGD
Gene Description FGFR1, fibroblast growth factor receptor 1, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of Fgfr1 may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and amplification and/or overexpression has been identified in colorectal cancer (PMID: 30181810), gastric cancer (PMID: 29976636), and breast cancer (PMID: 30119151).

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Molecular Profile Protein Effect Treatment Approaches
FGFR1 A121D no effect - predicted
FGFR1 A21T no effect - predicted
FGFR1 A263V no effect
FGFR1 A268S no effect - predicted
FGFR1 A431S unknown
FGFR1 A604T loss of function - predicted
FGFR1 A626V unknown
FGFR1 A645V loss of function
FGFR1 act mut gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 amp no effect FGFR Inhibitor (Pan) FGFR1 Inhibitor GSK3052230
FGFR1 amp FGFR2 amp
FGFR1 amp PIK3CA mut
FGFR1 amp NRAS amp
FGFR1 amp NRAS over exp
EML4 - ALK FGFR1 amp
FGFR2 fusion FGFR1 amp
FGFR1 amp FGFR1 over exp
FGFR1 W4C FGFR1 amp
FGFR1 C178S gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 C379R gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 C381R gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 C381Y no effect - predicted
FGFR1 D128N no effect - predicted
FGFR1 D128V unknown
FGFR1 D128Y unknown
FGFR1 D133dup unknown
FGFR1 D133E unknown
FGFR1 D133N no effect - predicted
FGFR1 D165_D166del unknown
FGFR1 D166del unknown
FGFR1 D320N unknown
FGFR1 D647N gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 D652G unknown
FGFR1 D90V no effect - predicted
FGFR1 dec exp no effect
FGFR1 E138* unknown
FGFR1 E334Q unknown
FGFR1 E360K no effect - predicted
FGFR1 E467K no effect - predicted
FGFR1 E592G no effect - predicted
FGFR1 E670G unknown
FGFR1 E765G unknown
FGFR1 fusion unknown
FGFR1 G610D unknown
FGFR1 G687R unknown
FGFR1 G687V unknown
FGFR1 G703S unknown
FGFR1 G70R unknown
FGFR1 H717N unknown
FGFR1 I544V gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 inact mut loss of function
FGFR1 K291E no effect - predicted
FGFR1 K517R unknown
FGFR1 K598N unknown
FGFR1 K655I unknown
FGFR1 K656* loss of function - predicted
FGFR1 K656D unknown
FGFR1 K656E gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 K656M gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 K656N unknown
FGFR1 K687E unknown
FGFR1 M563I FGFR1 K687E
FGFR1 V592M FGFR1 K687E
FGFR1 L122F no effect - predicted
FGFR1 L484M unknown
FGFR1 L573M unknown
FGFR1 L614V gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 M456I unknown
FGFR1 M456V no effect - predicted
FGFR1 M532T unknown
FGFR1 M563I unknown
FGFR1 M563T unknown
FGFR1 mutant unknown
FGFR1 N193fs loss of function - predicted
FGFR1 N330I unknown
FGFR1 N546D unknown
FGFR1 N546K gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
ALK F1174L FGFR1 N546K
FGFR1 over exp no effect FGFR Inhibitor (Pan) FGFR1 Inhibitor GSK3052230
FGFR1 over exp PIK3CA mut
FGFR1 P123S no effect - predicted
FGFR1 P150S unknown
FGFR1 P252R unknown
FGFR1 P252S gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 P252T gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 P277L unknown
FGFR1 P366L unknown
FGFR1 P483L no effect - predicted
FGFR1 P772L no effect - predicted
FGFR1 P772S no effect - predicted
FGFR1 positive unknown
FGFR1 pos FGFR2 pos
FGFR1 Q309* loss of function - predicted
FGFR1 R120H unknown
FGFR1 R189C unknown
FGFR1 R189H unknown
FGFR1 R209H no effect - predicted
FGFR1 R250Q loss of function
FGFR1 R250W unknown
FGFR1 R424C no effect - predicted
FGFR1 R445W unknown
FGFR1 R475Q no effect - predicted
FGFR1 R507H unknown
FGFR1 R576W unknown
FGFR1 R646L unknown
FGFR1 R646W loss of function - predicted
FGFR1 R78H unknown
FGFR1 R809Q unknown
FGFR1 R822C no effect - predicted
FGFR1 rearrange unknown FGFR Inhibitor (Pan)
FGFR1 S125L no effect - predicted
FGFR1 S135F unknown
FGFR1 S238N no effect - predicted
FGFR1 S430F unknown
FGFR1 S436F loss of function - predicted
FGFR1 S588T no effect - predicted
FGFR1 T141R no effect - predicted
FGFR1 T26I no effect - predicted
FGFR1 T319A loss of function - predicted
FGFR1 T340M no effect - predicted
FGFR1 T370A no effect - predicted
FGFR1 T658P unknown
FGFR1 T695A gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 V102I unknown
FGFR1 V273M no effect - predicted
FGFR1 V396I unknown
FGFR1 V444A unknown
FGFR1 V460A no effect - predicted
FGFR1 V561F unknown
FGFR1 V561M gain of function FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 V592M unknown
FGFR1 V664L loss of function - predicted
FGFR1 V751A loss of function - predicted
FGFR1 W4C unknown
FGFR1 W666R unknown
FGFR1 W684G unknown
FGFR1 wild-type no effect
FGFR1 Y307N no effect - predicted
FGFR1 Y372C gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor
FGFR1 Y374C gain of function - predicted FGFR Inhibitor (Pan) FGFR1 Inhibitor