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| Profile Name | FGFR1 C381R |
| Gene Variant Detail | |
| Relevant Treatment Approaches | FGFR Inhibitor (Pan) FGFR1 Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| FGFR1 C381R | Advanced Solid Tumor | sensitive | FGFR Inhibitor (Pan) | Erdafitinib | Preclinical - Cell culture | Actionable | In a preclinical study, Balversa (erdafitinib) inhibited colony formation and viability in cells expressing FGFR1 C381R in culture (PMID: 40526877). | 40526877 |
| FGFR1 C381R | Advanced Solid Tumor | sensitive | FGFR Inhibitor (Pan) | Futibatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Lytgobi (futibatinib) inhibited viability of cells expressing FGFR1 C381R in culture (PMID: 40526877). | 40526877 |
| FGFR1 C381R | Advanced Solid Tumor | sensitive | FGFR1 Inhibitor | Pemigatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Pemazyre (pemigatinib) inhibited viability of cells expressing FGFR1 C381R in culture (PMID: 40526877). | 40526877 |
| FGFR1 C381R | Advanced Solid Tumor | sensitive | FGFR1 Inhibitor | Fexagratinib | Preclinical - Cell culture | Actionable | In a preclinical study, Fexagratinib (AZD4547) inhibited viability of cells expressing FGFR1 C381R in culture (PMID: 40526877). | 40526877 |