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Gene Symbol | ATR | ||||||||||
Synonyms | FCTCS | FRP1 | MEC1 | SCKL | SCKL1 | ||||||||||
Gene Description | ATR, ATR serine/threonine kinase, is involved in regulation of the DNA damage response and mediation of cell-cycle checkpoints (PMID: 25512053). Loss of function ATR mutations have been identified in melanoma (PMID: 28273450), and inhibition of Atr selectively sensitizes cancerous cells to radiation and chemotherapy (PMID: 23583268, PMID: 31836456, PMID: 29054375). | ||||||||||
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Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
ATR A1896D | unknown | |
ATR A1896T | unknown | |
ATR A1934D | unknown | |
ATR A2002G | unknown | |
ATR A2165V | unknown | |
ATR A615S | unknown | |
ATR amp | no effect | |
ATR C347* | loss of function - predicted | |
ATR D1380Y | unknown | |
ATR D1470N | unknown | |
ATR D155E | unknown | |
ATR D1560N | unknown | |
ATR D2118N | unknown | |
ATR D2331Y | unknown | |
ATR D2494E | loss of function | |
ATR D983N | unknown | |
ATM del ATR dec exp | ||
ATR dec exp | no effect | |
ATR del | loss of function | |
ATR E1059* | loss of function - predicted | |
ATR E1229* | loss of function - predicted | |
ATR E1375G | unknown | |
ATR E1602D | unknown | |
ATR E2011K | unknown | |
ATR E2103A | unknown | |
ATR E2378V | unknown | |
ATR E254G | unknown | |
ATR E2626* | unknown | |
ATR E91* | loss of function - predicted | |
ATR F676fs | loss of function - predicted | |
ATR F732L | unknown | |
ATR G1181C | unknown | |
ATR G1181F | unknown | |
ATR G1181S | unknown | |
ATR G1181V | unknown | |
ATR G2530C | unknown | |
ATR H2153R | unknown | |
ATR H2203N | unknown | |
ATR H4R | unknown | |
ATR H90Y | unknown | |
ATR I1526V | unknown | |
ATR I1831S | unknown | |
ATR I1851V | unknown | |
ATR I219V | unknown | |
ATR I493M | unknown | |
ATR I774fs | loss of function - predicted | |
ATR I774Nfs*3 | loss of function - predicted | |
ATR I774Nfs*5 | loss of function - predicted | |
ATR I774Yfs*5 | loss of function - predicted | |
ATR inact mut | loss of function | |
ATR K2221E | unknown | |
ATR K2310N | unknown | |
ATR K297N | unknown | |
ATR K764E | unknown | |
ATR K771fs | loss of function - predicted | |
ATR L1361* | loss of function - predicted | |
ATR L1361V | unknown | |
ATR L1397M | unknown | |
ATR L1707I | unknown | |
ATR L1746I | unknown | |
ATR L1834F | unknown | |
ATR L2076V | unknown | |
ATR L2306F | unknown | |
ATR L2593I | unknown | |
ATR L298R | unknown | |
ATR M1162I | no effect | |
ATR M211I | unknown | |
ATR M211T | unknown | |
ATR M328V | unknown | |
ATR M335I | unknown | |
ATR mutant | unknown | |
ATR over exp | no effect | ATR Inhibitor |
ATR P1530Q | unknown | |
ATR positive | unknown | |
ATR Q1732L | unknown | |
ATR Q1845* | loss of function - predicted | |
ATR Q2635H | unknown | |
ATR Q412* | loss of function - predicted | |
ATR R1015Q | unknown | |
ATR R1025C | unknown | |
ATR R109L | unknown | |
ATR R109W | unknown | |
ATR R1183Q | unknown | |
ATR R1201C | unknown | |
ATR R1368* | loss of function - predicted | |
ATR R1412Q | unknown | |
ATR R1503* | loss of function - predicted | |
ATR R1647C | unknown | |
ATR R1724M | unknown | |
ATR R177Q | unknown | |
ATR R1814Efs*10 | loss of function - predicted | |
ATR R1814Kfs*8 | loss of function - predicted | |
ATR R1886* | loss of function - predicted | |
ATR R1886Q | unknown | |
ATR R2356C | unknown | |
ATR R2407C | unknown | |
ATR R2407H | unknown | |
ATR R2425Q | unknown | |
ATR R2514C | unknown | |
ATR R515H | unknown | |
ATR R968I | unknown | |
ATR R989C | unknown | |
ATR S1142G | unknown | |
ATR S1325C | unknown | |
ATR S1325N | unknown | |
ATR S1645F | unknown | |
ATR S601F | loss of function | |
ATR S684Y | unknown | |
ATR S902Y | unknown | |
ATR T1401A | unknown | |
ATR T2516I | unknown | |
ATR T2580N | unknown | |
ATR T541I | unknown | |
ATR V316I | unknown | |
ATR V915A | unknown | |
ATR V959M | unknown | |
ATR W1591L | unknown | |
ATR W2035C | unknown | |
ATR wild-type | no effect | |
ATR Y1404* | loss of function - predicted | |
ATR Y2132* | loss of function - predicted | |
ATR Y2132D | unknown | |
ATR Y2637C | unknown |