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Gene Symbol ARID1B
Synonyms 6A3-5 | BAF250B | BRIGHT | CSS1 | DAN15 | ELD/OSA1 | MRD12 | OSA2 | P250R | SMARCF2
Gene Description ARID1B, AT-rich interactive domain-containing protein 1B, is a member of the cBaF subunit (PMID: 32303701) of the SWI/SNF chromatin remodeling complex and is involved in cell-cycle activation (PMID: 15170388) and plays a role in neurodevelopment (PMID: 25674384). ARID1B mutations have been identified in several tumor types including, melanoma, gastric, colorectal, liver, neuroblastoma (PMID: 28521285), and pancreatic (PMID: 27737960) and decreased expression has been observed in ovarian clear cell carcinoma (PMID: 29890703).
NCBI Gene ID Chromosome Map Location Canonical Transcript Gene Role
57492 6 6q25.3 NM_017519 Tumor suppressor (PMID: 30606230)

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03925350 Phase II Niraparib Efficacy and Safety Study of Niraparib in Melanoma With Genetic Homologous Recombination (HR) Mutation Unknown status USA 0
NCT05687136 Phase I M1774 + Peposertib Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and M1774 for Advanced Solid Tumors Recruiting USA 0
NCT04633902 Phase II Olaparib + Pembrolizumab Phase II Study of Olaparib and Pembrolizumab in Advanced Melanoma With Homologous Recombination (HR) Mutation Recruiting USA 0