MAP2K1 K35N
Gene Variant Detail

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Gene MAP2K1
Variant K35N
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions MAP2K1 K35N does not lie within any known functional domains of the Map2k1 protein (UniProt.org). K35N induces Erk phosphorylation similar to wild-type Map2k1 in cultured cells (PMID: 32641410), and therefore, is predicted to have no effect on Map2k1 protein function.
Associated Drug Resistance
Category Variants Paths

MAP2K1 mutant MAP2K1 K35N

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Transcript NM_002755.4
gDNA chr15:g.66435051G>C
cDNA c.105G>C
Protein p.K35N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017022411 chr15:g.66435051G>C c.105G>C p.K35N RefSeq GRCh38/hg38
NM_001411065.1 chr15:g.66435117G>C c.105G>C p.K35N RefSeq GRCh38/hg38
XM_017022411.3 chr15:g.66435051G>C c.105G>C p.K35N RefSeq GRCh38/hg38
XM_011521783.4 chr15:g.66435117G>C c.105G>C p.K35N RefSeq GRCh38/hg38
XM_017022412 chr15:g.66435117G>C c.105G>C p.K35N RefSeq GRCh38/hg38
XM_017022412.1 chr15:g.66435117G>C c.105G>C p.K35N RefSeq GRCh38/hg38
NM_002755 chr15:g.66435051G>C c.105G>C p.K35N RefSeq GRCh38/hg38
NM_002755.3 chr15:g.66435051G>C c.105G>C p.K35N RefSeq GRCh38/hg38
XM_011521783.3 chr15:g.66435117G>C c.105G>C p.K35N RefSeq GRCh38/hg38
NM_002755.4 chr15:g.66435051G>C c.105G>C p.K35N RefSeq GRCh38/hg38
XM_011521783 chr15:g.66435117G>C c.105G>C p.K35N RefSeq GRCh38/hg38
XM_017022411.2 chr15:g.66435051G>C c.105G>C p.K35N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References