ATRX G1589E
Gene Variant Detail

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Gene ATRX
Variant G1589E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATRX G1589E lies within the helicase ATP-binding domain of the Atrx protein (UniProt.org). G1589E has not been characterized in the scientific literature and therefore, its effect on Atrx protein function is unknown (PubMed, Feb 2026).
Associated Drug Resistance
Category Variants Paths

ATRX mutant ATRX G1589E

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Transcript NM_000489.6
gDNA chrX:g.77634637C>T
cDNA c.4766G>A
Protein p.G1589E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006724668.4 chrX:g.77634637C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
NM_000489.4 chrX:g.77634637C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
NM_000489 chrX:g.77634637C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
XM_005262156.4 chrX:g.77633591C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
XM_006724668 chrX:g.77634637C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
XM_006724667 chrX:g.77633295_77633296delGCinsCT c.4766_4767delGCinsAG p.G1589E RefSeq GRCh38/hg38
XM_005262156 chrX:g.77633591C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
XM_006724668.3 chrX:g.77634637C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
XM_005262156.5 chrX:g.77633591C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
NM_000489.6 chrX:g.77634637C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38
XM_006724667.3 chrX:g.77633295_77633296delGCinsAG c.4766_4767delGCinsAG p.G1589E RefSeq GRCh38/hg38
XM_047442191.1 chrX:g.77634637C>T c.4766G>A p.G1589E RefSeq GRCh38/hg38

Filtering

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References