ALK F1174C
Gene Variant Detail

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Gene ALK
Variant F1174C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions ALK F1174C lies within the protein kinase domain of the Alk protein (UniProt.org). F1174C confers a gain of function to Alk, as indicated by constitutive Alk phosphorylation (PMID: 24509625), and increased cell viability in culture (PMID: 29559559).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK act mut ALK F1174C

ALK mutant ALK F1174X ALK F1174C

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Transcript NM_004304.5
gDNA chr2:g.29220830A>C
cDNA c.3521T>G
Protein p.F1174C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29220830A>C c.3521T>G p.F1174C RefSeq GRCh38/hg38
NM_004304 chr2:g.29220830A>C c.3521T>G p.F1174C RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29220830A>C c.3521T>G p.F1174C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK F1174C Advanced Solid Tumor predicted - sensitive TPX-0131 Preclinical - Biochemical Actionable In a preclinical study, TPX-0131 inhibited kinase activity of ALK F1174C in an in vitro assay (PMID: 34158340). 34158340
ALK F1174C neuroblastoma predicted - sensitive Cyclophosphamide + Doxorubicin + Lorlatinib + Vincristine Sulfate Preclinical - Pdx Actionable In a preclinical study, the combination of Lorbrena (lorlatinib), Cytoxan (cyclophosphamide), Adriamycin (doxorubicin), and Oncovin (vincristine) resulted in modest inhibition of tumor growth in a patient-derived xenograft (PDX) model of neuroblastoma harboring ALK F1174C (PMID: 36602782). 36602782
ALK F1174C neuroblastoma predicted - sensitive Lorlatinib Case Reports/Case Series Actionable In a Phase I trial, Lorbrena (lorlatinib) treatment resulted in a partial response in a neuroblastoma patient harboring ALK F1174C, along with CDKN2A A102V (PMID: 37147298; NCT03107988). 37147298
ALK F1174C prostate small cell carcinoma predicted - sensitive Alectinib Case Reports/Case Series Actionable In a clinical case report, Alecensa (alectinib) treatment in a patient with prostate small cell carcinoma harboring ALK F1174C resulted in stable disease and a decrease in ALK F1174C allele fraction in circulating tumor DNA, with clinical benefit ongoing after 7 months (PMID: 29559559). 29559559